Autotransplantation for tumors of the brain
What is a transplant? What’s it used for? Why a transplant?
Speaking of “transplantation”, “transplant” doctors and parents use medical jargon. The method discloses another slang word “Vysocanska” And so, everything in order.
The concept VHT – high-dose chemotherapy, “Vysocanska”. Chemotherapy with increasing doses of anticancer drugs from 4 to 10 times compared to the doses used in the regular courses. Why, You ask? Let’s face it.
As a Preface.
All modern achievements of Oncology based on a comprehensive approach of cancer therapy. In the realities of the present time, only use the entire Arsenal of anticancer methods allow, will get the desired result.
So what, armed with modern recobrar? Consider the Arsenal of neuro-Oncology.
Surgical treatment. (mechanical removal of the tumor).
Radiation therapy. (the use of high energy radiation to destroy malignant cells). May include standard schemes of therapy of gamma to high precision, such as gamma knife.
Drug therapy (chemotherapy). (exposure to chemicals (drugs) on tumor cells). Including high-dose chemotherapy.
Targeted therapy (from the English word target – the target on Russian language can be translated as the target, i.e. the drug works against specific targets in the cell, without affecting the body). Most young method of therapy of CNS tumors, but also the fastest growing.A focused method of treatment – the drugs act on a specific target on a tumour cell. One of the most promising areas of modern pharmacology, which undoubtedly brings us closer to creating the perfect drug, the implementation of the principle of the “Golden bullets”, formulated by Paulam Elifom at the beginning of the last century, the destruction of only the tumour cells without causing any harm to the body.
Immunotherapy – the use of the activation of the immune system of the patient to combat the tumor. Is determined by two main directions of immunocorrective and antitumor vaccination.
Method WHT as one of the stages of drug treatment, usually the final?
Under this section we will look at methods of drug therapy and method of high-intensity (high-dose) therapy.
Anticancer drugs can cause the death of malignant cells. For each tumor sensitivity to various drugs, some tumors are not sensitive to drug therapy, for others, developed enough effective drugs. Drugs used in mono-therapy (one drug) or in combination. Most frequently to improve efficiency, use of a combination of several drugs. Conduct drug treatment may vary according to the number of injections, duration and intensity.
For tumors which are sensitive to chemotherapy are very attractive strategies is the increasing doses of chemotherapy, which will lead to better treatment outcomes. It is known that the higher the concentration, the higher the antitumor activity. So during the course of high-dose chemotherapy the dose of some drugs is increased 10 times compared with conventional. However, undesirable effects of this therapy are the toxic effects on healthy cells in the body. The most “destructive” are exposed to blood cells. The child becomes defenceless before any infection, he needs blood products. Without transplantation, the period of aplasia (insecurity) can last for months, and transfer this test small the patient will hardly afford. To reduce this threat period to the child after intensive treatment, administered his own prepared in advance, hematopoietic stem cells. They were removed from the “impact” of chemotherapy and has retained its activity. Cells return to the bone marrow and regenerate blood and immune system. The duration of the “vulnerable” period is greatly reduced, that is why this method is also called “rescue therapy”.
In conclusion of the topic, I want to clarify that high-dose chemotherapy with subsequent transplantation is carried out, due to the lack of safer and more effective ways to help the child. Technology is highly intensive and is characterized by a significant number of complications, it is performed in highly specialized departments of reanimation Department. Requires coordinated work of professionally trained personnel, a large number of modern equipment and very expensive medicines. However, currently, this is the only way which can help to cure even very heavy patients.
Who can benefit from high-dose chemotherapy (WHT) with transplantation of own stem cells?
Select three groups of patients.
I. Patients with primary CNS tumors.
Medulloblastoma (MB) and supratentorial located, pneo (spnet DLL) Protocol SJMB-96 (held 4 courses of high-intensity chemotherapy with transplantatie autogps after each course).
II. Patients with primary CNS tumors, which in the final phase, the consolidation phase is WHT. (consolidation – strengthening, strengthening effect).
a. Medulloblastoma and pneo (spnet DLL) is treated outside the Protocol SJMB.
b. ATRO (atypical teratoid abdeidna tumor) c. Pinealoblastoma d. Retinoblastoma (patients high-risk groups) e. Neuroblastoma (patients at high risk)
III. Patients with recurrent CNS tumors.
a. Medulloblastoma and pneo (spnet DLL).
b. Germ cell tumors (germinoma).
c. Retinoblastoma d. Neuroblastoma
This publication will help You understand the principles of high dose chemotherapy with stem cell transplantation.